Men's health journal
Volume:1 Issue: 1, Winter 2017

Adrenal cavernous hemangioma is a rare benign tumor, most commonly diagnosed incidentally on imaging stud-ies. Hereby we report a case of adrenal cavernous hemangioma with myelolipoma in a 39-year-old female pre-senting with epigastric pain for six months. CT scan of abdomen and pelvis showed a 38*27 mm left adrenal mass with heterogeneous enhancement and calcification. Laparoscopic left adrenalectomy was performed and patho-logic examination grossly showed an encapsulated oval mass with multicystic cut surfaces containing hematoma. Microscopically, blood filled dilated vascular channels lined by endothelial cells with foci of adipose tissue ad-mixed with normal hematopoietic cells were seen. Positive immunostaining for CD31 and CD34 confirmed the diagnosis of cavernous hemangioma. So, cavernous hemangioma associated with myelolipoma of the adrenal gland should always be considered as a differential diagnosis of adrenal masses.

Obstructive azoospermia is one of the causes of post-testicular infertility in men and previous studies have reported inconsistent levels of endothelial nitric oxide synthase (eNOS) enzyme in these patients. Accordingly, the present study aimed to provide further evidence on the expression of eNOS enzyme in patients with azoospermia. In this case-control study, 10 patients, who were diagnosed with azoospermia and were referred to the infertility center for treatment or diagnosis, and 7 healthy fertile men were recruited. An informed written consent was obtained from included subjects and they underwent testicular biop-sies. Samples were assessed via immunohistochemical methods to determine their levels of eNOS expression. Both leydig and sertoli cells were found to express eNOS, while this enzyme was not expressed in normal germinal cells. The only significant difference between the two groups was the level of eNOS expression in sertoli cells which was found to be higher in patients with obstructive azoospermia compared to the control group (P<0.001). According to the results of this study, sertoli cells and their interactions with germinal cells of seminiferous tubule might play an important role in sperm quality and a subsequent successful fertiliza-tion.